Perdition
Definition: hell, damnation, ruin
It’s from the Latin root for “to throw away, to destroy.”
Why I Looked It Up
From Team of Rivals, when the Secretary of State was trying to persuade the President to take action.
perdition [is] the sure penalty of further hesitation
I also remember a 2002 movie called Road to Perdition, which is based on a series of comics. “Road to perdition” might be interpreted as “highway to hell” or “path to ruin.”
Update
Added on
The Medici: Power, Money, and Ambitions in the Italian Renaissance describes a Papal bull issued in the late 1400s that referred to someone as “a suckling of perdition.”